Phenotypes associated with this allele

• Allele Symbol: Zdhhc19^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:6838376
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zdhhc19^em1Cya/Zdhhc19^em1Cya	C57BL/6N-Zdhhc19^em1Cya/Cya	MGI:6838379

Genotype
MGI:6838379

hm1

• Allelic Composition: Zdhhc19^em1Cya/Zdhhc19^em1Cya
• Genetic Background: C57BL/6N-Zdhhc19^em1Cya/Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

coiled sperm flagellum ( J:316357 )

♂

kinked sperm flagellum ( J:316357 )

♂ • bent

abnormal sperm head morphology ( J:316357 )

♂

asthenozoospermia ( J:316357 )

♂ • sperm exhibit reduced total velocity, curvilinear velocity, lateral head displacement, and beat/cross frequency compared with wild-type cells

♂ • however, straight line velocity and average path velocity is normal

male infertility ( J:316357 )

♂ • despite normal testes size and spermatogenesis

impaired acrosome reaction ( J:316357 )

♂

decreased fertilization frequency ( J:316357 )

♂ • of cumulus intact oocytes

cellular

coiled sperm flagellum ( J:316357 )

♂

kinked sperm flagellum ( J:316357 )

♂ • bent

abnormal sperm head morphology ( J:316357 )

♂

asthenozoospermia ( J:316357 )

♂ • sperm exhibit reduced total velocity, curvilinear velocity, lateral head displacement, and beat/cross frequency compared with wild-type cells

♂ • however, straight line velocity and average path velocity is normal