reproductive system
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• male mice exhibit normal fertility
|
|
• increased time to undergo germinal vesicle breakdown in culture and time to extrude the first polar body
• 4-fold increase in aneuploidy rates
• delayed and erroneous chromosome alignment
• impaired chromosome-microtubule attachment in metaphase I and II
• however, older mice exhibit normal polar body extrusion
|
|
• increased time to extrude the first polar body
|
|
• reduced spindle integrity in oocytes
|
cellular
|
• increased time to undergo germinal vesicle breakdown in culture and time to extrude the first polar body
• 4-fold increase in aneuploidy rates
• delayed and erroneous chromosome alignment
• impaired chromosome-microtubule attachment in metaphase I and II
• however, older mice exhibit normal polar body extrusion
|
|
• increased time to extrude the first polar body
|
|
• reduced spindle integrity in oocytes
|