Phenotypes associated with this allele

• Allele Symbol: Tmem41b^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:6838393
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem41b^em1Cya/Tmem41b^em1Cya	involves: C57BL/6	MGI:6838394
ht2	Tmem41b^em1Cya/Tmem41b^+	involves: C57BL/6	MGI:6838395

Genotype
MGI:6838394

hm1

• Allelic Composition: Tmem41b^em1Cya/Tmem41b^em1Cya
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:316472 )

Genotype
MGI:6838395

ht2

• Allelic Composition: Tmem41b^em1Cya/Tmem41b⁺
• Genetic Background: involves: C57BL/6

immune system

decreased susceptibility to Coronaviridae infection ( J:316472 )

• display reduced weight loss and delayed disease progression following infection with 5x10^5 plaque forming units of MHV-A59

• liver necrosis and damage are reduced following MHV-A59 infection, with only focal areas of necrosis found compared to extensive necrotic areas in livers of similarly infected wild-type mice

• post infection with MHV-A59 viral titers are lower than in similarly infected wild-type controls

cellular

impaired autophagy ( J:316472 )

• accumulation of p62 in the liver and kidneys indicating impaired autophagic flux

homeostasis/metabolism

impaired autophagy ( J:316472 )

• accumulation of p62 in the liver and kidneys indicating impaired autophagic flux

decreased circulating cholesterol level ( J:316472 )

• lower total cholesterol level in the serum

decreased circulating LDL cholesterol level ( J:316472 )

decreased circulating triglyceride level ( J:316472 )