About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ahcyem1Cya
endonuclease-mediated mutation 1, Cyagen Biosciences
MGI:6838413
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ahcyem1Cya/Ahcy+ C57BL/6N-Ahcyem1Cya/Cya MGI:6840217


Genotype
MGI:6840217
ht1
Allelic
Composition		 Ahcyem1Cya/Ahcy+
Genetic
Background		 C57BL/6N-Ahcyem1Cya/Cya
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahcyem1Cya mutation (0 available); any Ahcy mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vasodilation ( J:298071 )
• in response to precontraction with phenylephrine and relaxation with acetylcholine, mice with or without indomethacin exhibit endothelial dysfunction compared with control mice
• however, relaxation in response to nitroprusside is normal

cellular

homeostasis/metabolism
abnormal nitric oxide homeostasis ( J:298071 )
• reduced aortic concentration in response to precontraction with phenylephrine and relaxation with acetylcholine

muscle
abnormal vasodilation ( J:298071 )
• in response to precontraction with phenylephrine and relaxation with acetylcholine, mice with or without indomethacin exhibit endothelial dysfunction compared with control mice
• however, relaxation in response to nitroprusside is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory