About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		C2cd6tm1Jw
targeted mutation 1, Jeremy Wang
MGI:6842332
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		C2cd6tm1Jw/C2cd6tm1Jw involves: 129S4/SvJae * C57BL/6 MGI:6842361


Genotype
MGI:6842361
hm1
Allelic
Composition		 C2cd6tm1Jw/C2cd6tm1Jw
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C2cd6tm1Jw mutation (0 available); any C2cd6 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:316788 )
N
• female mice exhibit normal fertility
abnormal sperm flagellum morphology ( J:316788 )
• reduced CatSper calcium channel capacity
decreased hyperactivated sperm motility ( J:316788 )
• sperm fail to exhibit hyperactivity unlike wild-type sperm
• however, total progressive sperm motility is normal
male infertility ( J:316788 )
• despite normal testes weight and sperm morphology
impaired fertilization ( J:316788 )
• of eggs of female mice mated with mutant males
• however, intracytoplasmic sperm injection produces fertilization and treatment with ionophore and sperm energy restriction increases fertilization rate

cellular
abnormal sperm flagellum morphology ( J:316788 )
• reduced CatSper calcium channel capacity
decreased hyperactivated sperm motility ( J:316788 )
• sperm fail to exhibit hyperactivity unlike wild-type sperm
• however, total progressive sperm motility is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory