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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		C2cd6tm1Jw
targeted mutation 1, Jeremy Wang
MGI:6842332
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		C2cd6tm1Jw/C2cd6tm1Jw involves: 129S4/SvJae * C57BL/6 MGI:6842361


Genotype
MGI:6842361
hm1
Allelic
Composition		 C2cd6tm1Jw/C2cd6tm1Jw
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C2cd6tm1Jw mutation (0 available); any C2cd6 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:316788 )
N
• female mice exhibit normal fertility
abnormal sperm flagellum morphology ( J:316788 )
• reduced CatSper calcium channel capacity
decreased hyperactivated sperm motility ( J:316788 )
• sperm fail to exhibit hyperactivity unlike wild-type sperm
• however, total progressive sperm motility is normal
male infertility ( J:316788 )
• despite normal testes weight and sperm morphology
impaired fertilization ( J:316788 )
• of eggs of female mice mated with mutant males
• however, intracytoplasmic sperm injection produces fertilization and treatment with ionophore and sperm energy restriction increases fertilization rate

cellular
abnormal sperm flagellum morphology ( J:316788 )
• reduced CatSper calcium channel capacity
decreased hyperactivated sperm motility ( J:316788 )
• sperm fail to exhibit hyperactivity unlike wild-type sperm
• however, total progressive sperm motility is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory