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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nclem1Mfz
endonuclease-mediated mutation 1, Mike Fainzilber
MGI:6842504
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nclem1Mfz/Nclem1Mfz involves: BALB/cAnNHsd * C57BL/6JOlaHsd * C57BL/6NHsd MGI:6842508
hm2
 		Nclem1Mfz/Nclem1Mfz involves: BALB/cAnNHsd * C57BL/6NHsd * ICR MGI:6842510
ht3
 		Nclem1Mfz/Ncl+ either: (involves: BALB/cAnNHsd * C57BL/6JOlaHsd * C57BL/6NHsd) or (involves: BALB/cAnNHsd * C57BL/6NHsd * ICR) MGI:6842512


Genotype
MGI:6842508
hm1
Allelic
Composition		 Nclem1Mfz/Nclem1Mfz
Genetic
Background		 involves: BALB/cAnNHsd * C57BL/6JOlaHsd * C57BL/6NHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nclem1Mfz mutation (1 available); any Ncl mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:6842510
hm2
Allelic
Composition		 Nclem1Mfz/Nclem1Mfz
Genetic
Background		 involves: BALB/cAnNHsd * C57BL/6NHsd * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nclem1Mfz mutation (1 available); any Ncl mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:312459 )
• no 3- to 4-week old pups were recovered




Genotype
MGI:6842512
ht3
Allelic
Composition		 Nclem1Mfz/Ncl+
Genetic
Background		 either: (involves: BALB/cAnNHsd * C57BL/6JOlaHsd * C57BL/6NHsd) or (involves: BALB/cAnNHsd * C57BL/6NHsd * ICR)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nclem1Mfz mutation (1 available); any Ncl mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon extension ( J:312459 )
• accelerated axonal outgrowth in cultured neurons

cellular
abnormal axon extension ( J:312459 )
• accelerated axonal outgrowth in cultured neurons




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory