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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spata33em1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:6849782
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Spata33em1Osb/Spata33em1Osb involves: C57BL/6NJcl * DBA/2NJcl MGI:6849948


Genotype
MGI:6849948
hm1
Allelic
Composition		 Spata33em1Osb/Spata33em1Osb
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spata33em1Osb mutation (2 available); any Spata33 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:309565 )
N
• sperm morphology is normal
abnormal sperm motility ( J:309565 )
• decrease in average path velocity, straight-line velocity, and curvilinear velocity
• however, the percentage of motile sperm is normal
reduced male fertility ( J:309565 )
• severely impaired fertility
impaired fertilization ( J:309565 )
• using mutant sperm in vitro despite removing the cumulus cells
• however, removing the cumulus cells and zona pellucida restores fertilization

cellular
abnormal sperm motility ( J:309565 )
• decrease in average path velocity, straight-line velocity, and curvilinear velocity
• however, the percentage of motile sperm is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory