Analysis Tools
skeleton
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• mice exhibit enhanced osteoclast formation as indicated by upregulation of osteoclastogenic genes
• osteoclast precursors exhibit increased osteoclast differentiation
|
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• mice exhibit an increase in multi-nucleated TRAP-positive osteoclasts
• however, no difference in the number of osteoblasts is seen
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osteoporosis
(
J:317012
)
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• mice exhibit an osteoporotic phenotype in the trabecular bone of the tibia, calvaria, and lumbar
• low bone mass is caused by bone resorption due to enhanced osteoclast formation
|
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• the area of the calvarial bone marrow cavity, an index of bone resorption activity, and the level of urinary deoxypyridinoline, a marker of bone resorption, are increased
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growth/size/body
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• slight decrease in body weight
• however, all other appearances including body size, tooth eruption, locomotor activity and bone-related parameters in the serum are normal
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hematopoietic system
|
• mice exhibit enhanced osteoclast formation as indicated by upregulation of osteoclastogenic genes
• osteoclast precursors exhibit increased osteoclast differentiation
|
|
• mice exhibit an increase in multi-nucleated TRAP-positive osteoclasts
• however, no difference in the number of osteoblasts is seen
|
immune system
|
• mice exhibit enhanced osteoclast formation as indicated by upregulation of osteoclastogenic genes
• osteoclast precursors exhibit increased osteoclast differentiation
|
|
• mice exhibit an increase in multi-nucleated TRAP-positive osteoclasts
• however, no difference in the number of osteoblasts is seen
|
cellular
|
• mice exhibit enhanced osteoclast formation as indicated by upregulation of osteoclastogenic genes
• osteoclast precursors exhibit increased osteoclast differentiation
|
