Phenotypes associated with this allele

• Allele Symbol: Cemip2^tm1.1Cya
• Allele Name: targeted mutation 1.1, Cyagen Biosciences
• Allele ID: MGI:6854703
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cemip2^tm1.1Cya/Cemip2^tm1.1Cya Tg(CAG-cre/Esr1*)5Amc/0	involves: C57BL/6 * CBA	MGI:7616226

Genotype
MGI:7616226

cn1

• Allelic Composition: Cemip2^tm1.1Cya/Cemip2^tm1.1Cya; Tg(CAG-cre/Esr1*)5Amc/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal bone marrow cavity morphology ( J:317425 )

• hyaluronan deposits in the bone marrow matrix in tamoxifen treated mice

homeostasis/metabolism

increased hyaluronic acid level ( J:317425 )

• in tamoxifen treated mice tissue hyaluronan levels are increased in the liver, lung, and kidney

• prominent hyaluronan deposits in the lymph nodes

• deposits are also seen in the liver sinusoid, alveolar wall of the lung, mesangium of the kidney, the dermis, and the bone marrow matrix

increased circulating hyaluronic acid level ( J:317425 )

• rapid accumulation of hyaluronan in the blood at 12 and 19 days after tamoxifen treatment

• hyaluronan population contains a significant amount of undigested high molecular weight species

abnormal metabolism ( J:317425 )

• significant reduction of hyaluronan fragmentation in the lymph nodes and liver indicating reduced degradation in tamoxifen treated mice

integument

abnormal dermal layer morphology ( J:317425 )

• hyaluronan deposits in tamoxifen treated mice

respiratory system

abnormal pulmonary alveolus morphology ( J:317425 )

• hyaluronan deposits in tamoxifen treated mice

renal/urinary system

abnormal renal corpuscle morphology ( J:317425 )

• hyaluronan deposits in tamoxifen treated mice

cardiovascular system

abnormal liver sinusoid morphology ( J:317425 )

• hyaluronan deposits in tamoxifen treated mice

immune system

abnormal lymph node morphology ( J:317425 )

• prominent hyaluronan deposits in the lymph nodes in tamoxifen treated mice

liver/biliary system

abnormal liver sinusoid morphology ( J:317425 )

• hyaluronan deposits in tamoxifen treated mice