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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Doc2gtm1.2Aljg
targeted mutation 1.2, Alexander J Groffen
MGI:6856664
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Doc2gtm1.2Aljg/Doc2gtm1.2Aljg C57BL/6(Cg)-Doc2gtm1.2Aljg MGI:7736689
cx2
 		Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Doc2gtm1.2Aljg/Doc2gtm1.2Aljg
Rph3atm1Sud/Rph3atm1Sud
Syt7tm1Sud/Syt7tm1Sud 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7738542
cx3
 		Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Doc2gtm1.2Aljg/Doc2gtm1.2Aljg 		involves: 129P2/OlaHsd * C57BL/6 MGI:7738540


Genotype
MGI:7736689
hm1
Allelic
Composition		 Doc2gtm1.2Aljg/Doc2gtm1.2Aljg
Genetic
Background		 C57BL/6(Cg)-Doc2gtm1.2Aljg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2gtm1.2Aljg mutation (0 available); any Doc2g mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:317639 )
N
• mice are viable

nervous system
nervous system phenotype ( J:317639 )
N
• mice show no effect on spontaneous or evoked neurotransmitter release in glutamatergic hippocampal neurons, cultured either in networks or on microglial islands (autapses)

reproductive system
reproductive system phenotype ( J:317639 )
N
• mice are fertile




Genotype
MGI:7738542
cx2
Allelic
Composition		 Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Doc2gtm1.2Aljg/Doc2gtm1.2Aljg
Rph3atm1Sud/Rph3atm1Sud
Syt7tm1Sud/Syt7tm1Sud
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2atm1Ytk mutation (0 available); any Doc2a mutation (15 available)
Doc2btm1Aljg mutation (0 available); any Doc2b mutation (20 available)
Doc2gtm1.2Aljg mutation (0 available); any Doc2g mutation (11 available)
Rph3atm1Sud mutation (1 available); any Rph3a mutation (43 available)
Syt7tm1Sud mutation (1 available); any Syt7 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal synaptic plasticity ( J:317639 )
• short-term plasticity is altered by accentuating short-term depression
abnormal synaptic depression ( J:317639 )
• hippocampal neurons show more pronounced short-term depression
• the deeper short-term depression is not associated with changes in evoked release during burst stimuli
decreased paired-pulse ratio ( J:317639 )
• hippocampal neurons show reduced paired-pulse ratio with a more pronounced short-term depression
• however, spontaneous neurotransmitter release in glutamatergic hippocampal neurons is unaltered




Genotype
MGI:7738540
cx3
Allelic
Composition		 Doc2atm1Ytk/Doc2atm1Ytk
Doc2btm1Aljg/Doc2btm1Aljg
Doc2gtm1.2Aljg/Doc2gtm1.2Aljg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Doc2atm1Ytk mutation (0 available); any Doc2a mutation (15 available)
Doc2btm1Aljg mutation (0 available); any Doc2b mutation (20 available)
Doc2gtm1.2Aljg mutation (0 available); any Doc2g mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased neurotransmitter release ( J:317639 )
• mice show no additional effect on spontaneous or evoked neurotransmitter release in glutamatergic hippocampal neurons, cultured either in networks or on microglial islands (autapses) compared to that seen in the double Doc2atm1Ytk and Doc2btm1Aljb homozygotes




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory