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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ebna1bp2em1(IMPC)Tcp
endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI:6856862
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ebna1bp2em1(IMPC)Tcp/Ebna1bp2em1(IMPC)Tcp C57BL/6N-Ebna1bp2em1(IMPC)Tcp/Cmmr MGI:7414872
ht2
 		Ebna1bp2em1(IMPC)Tcp/Ebna1bp2+ C57BL/6N-Ebna1bp2em1(IMPC)Tcp/Cmmr MGI:7414871


Genotype
MGI:7414872
hm1
Allelic
Composition		 Ebna1bp2em1(IMPC)Tcp/Ebna1bp2em1(IMPC)Tcp
Genetic
Background		 C57BL/6N-Ebna1bp2em1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebna1bp2em1(IMPC)Tcp mutation (2 available); any Ebna1bp2 mutation (20 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ebna1bp2em1(IMPC)Tcp/Ebna1bp2em1(IMPC)Tcp mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as compacted morulas. Mutants fail to hatch from the zona pellucida and are dead after 3 days in culture.

embryo
failure of blastocyst to hatch from the zona pellucida ( J:279207 )
• in vitro, embryos fail to hatch from the zona pellucida and are dead after 3 days in culture
failure of morula compaction ( J:279207 )
• embryos recovered at E3.5 appear as partially compacted morulae

mortality/aging
embryonic lethality before implantation, complete penetrance ( J:279207 )
• homozygous embryos are recovered at E3.5 (14% versus expected 25%, n=28) and appear as partially compacted morulae; no homozygous embryos or excess resorption sites are observed at E7.5




Genotype
MGI:7414871
ht2
Allelic
Composition		 Ebna1bp2em1(IMPC)Tcp/Ebna1bp2+
Genetic
Background		 C57BL/6N-Ebna1bp2em1(IMPC)Tcp/Cmmr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebna1bp2em1(IMPC)Tcp mutation (2 available); any Ebna1bp2 mutation (20 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

growth/size/body
enlarged kidney ( J:211773 )
IMPC - TCP
enlarged spleen ( J:211773 )
IMPC - TCP

hematopoietic system
enlarged spleen ( J:211773 )
IMPC - TCP

immune system
enlarged spleen ( J:211773 )
IMPC - TCP

renal/urinary system
enlarged kidney ( J:211773 )
IMPC - TCP

reproductive system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory