All Phenotypes Fdps<tm1Jiy> MGI Mouse

premature death ( J:317808 )

• mice show poor overall survival, with most mice dying within 4 months after birth

increased myocardial fiber size ( J:317808 )

• cross-sectional area of cardiomyocytes is increased at 2 months of age

enlarged heart ( J:317808 )

• hearts show enlargement beginning at 2 months of age

• mice show age-specific increases in chamber volume

increased heart weight ( J:317808 )

• mice exhibit a greater heart weight and heart weight to body weight ratio at 2 months of age

• mice treated with a farnesyltransferase inhibitor FTI-277 exhibit reduced heart weight/body weight ratio

cardiac hypertrophy ( J:317808 )

• expression of hypertrophic makers begins to increase at 1 month of age indicating cardiac hypertrophy

cardiac interstitial fibrosis ( J:317808 )

• diffuse interstitial fibrosis is seen in hearts from 3 months onward

increased cardiac stroke volume ( J:317808 )

• stroke volume gradually increases

decreased cardiac muscle contractility ( J:317808 )

• fractional shortening and ejection fraction begin to decline at 2 months of age

• mice treated with a farnesyltransferase inhibitor FTI-277 exhibit improved cardiac function

abnormal heart echocardiography feature ( J:317808 )

• transthoracic echocardiography shows that ejection fraction and fractional shortening begin to decline at 2 months of age and end diastolic volume (EDV), end systolic volume (ESV), left ventricular internal dimension in diastole (LVIDd), left ventricular internal dimension in systole (LVIDs) and stroke volume gradually increase

• however, no difference in left ventricular posterior wall thickness in diastole (LVPWd) is seen