Phenotypes associated with this allele

• Allele Symbol: Fam120b^em1Qqlg
• Allele Name: endonuclease-mediated mutation 1, Qinqiang Long
• Allele ID: MGI:6863921
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fam120b^em1Qqlg/Fam120b^em1Qqlg	C57BL/6-Fam120b^em1Qqlg	MGI:6863939

Genotype
MGI:6863939

hm1

• Allelic Composition: Fam120b^em1Qqlg/Fam120b^em1Qqlg
• Genetic Background: C57BL/6-Fam120b^em1Qqlg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:318650 )

N • mice exhibit normal survival

cardiovascular system

increased myocardial fiber size ( J:318650 )

• slightly increased surface area at 3 months of age

myocardial fiber disarray ( J:318650 )

increased fetal cardiomyocyte size ( J:318650 )

• increased surface area at P1

thin interventricular septum ( J:318650 )

decreased heart weight ( J:318650 )

• slightly decreased relative to body weight at P1 and at 3 months of age

decreased heart left ventricle size ( J:318650 )

• decreased volume

decreased cardiac stroke volume ( J:318650 )

• with decreased systolic and diastolic function

decreased heart ventricle muscle contractility ( J:318650 )

• at 3 months of age

decreased fetal cardiomyocyte proliferation ( J:318650 )

cellular

decreased fetal cardiomyocyte proliferation ( J:318650 )

abnormal DNA repair ( J:318650 )

• increased DNA damage in cardiomyocytes of 12 week old mice

homeostasis/metabolism

abnormal DNA repair ( J:318650 )

• increased DNA damage in cardiomyocytes of 12 week old mice

muscle

increased myocardial fiber size ( J:318650 )

• slightly increased surface area at 3 months of age

myocardial fiber disarray ( J:318650 )

decreased heart ventricle muscle contractility ( J:318650 )

• at 3 months of age

decreased fetal cardiomyocyte proliferation ( J:318650 )