Phenotypes associated with this allele

• Allele Symbol: Lbx1^em1Mwil
• Allele Name: endonuclease-mediated mutation 1, Megan J Wilson
• Allele ID: MGI:6864154
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lbx1^em1Mwil/Lbx1^em1Mwil	Not Specified	MGI:7266351

Genotype
MGI:7266351

hm1

• Allelic Composition: Lbx1^em1Mwil/Lbx1^em1Mwil
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:319391 )

• die at birth

cardiovascular system

increased heart atrium size ( J:319391 )

• at E15.5 and E18.5

abnormal semilunar valve morphology ( J:319391 )

• at E15.5 and E18.5

increased heart left ventricle wall thickness ( J:319391 )

• thickened left ventricular wall at E15.5 and E18.5

nervous system

decreased neuron number ( J:319391 )

• decreased in the number of dorsal horn neurons at E18.5

abnormal spinal cord morphology ( J:319391 )

• peripherally projecting neurons show darker stained shortened axons present through the midline region of the spinal cord with premature termination of axons

• axons projecting from the dorsal root into the dorsal horn are absent

decreased motor neuron number ( J:319391 )

• smaller population with a distinct lack of peripherally extending neurons

• medial motor axons, projecting towards the ventral root and midline, are absent

abnormal dorsal interneuron 3 morphology ( J:319391 )

• dI3 cells often migrate in a more random direction compared to wild-type controls

abnormal dorsal interneuron 4 morphology ( J:319391 )

• expression analysis indicates loss of dI4 interneurons

abnormal dorsal interneuron 5 morphology ( J:319391 )

• expression analysis indicates loss of dI5 interneurons

abnormal spinal cord dorsal horn morphology ( J:319391 )

• decreased in the number of dorsal horn neurons at E18.5

skeleton

short tibia ( J:319391 )

• at E18.5

small vertebrae ( J:319391 )

• at E18.5

short vertebral column ( J:319391 )

• at E18.5 overall spine length is decreased by about 6.5%

limbs/digits/tail

limbs/digits/tail phenotype ( J:319391 )

N • distinct muscle groups are present at E18.5 suggesting myoblast migration to the developing limb is undisturbed

short tibia ( J:319391 )

• at E18.5