Phenotypes associated with this allele

• Allele Symbol: Minpp1^em1Vca
• Allele Name: endonuclease-mediated mutation 1, Vincent Cantagrel
• Allele ID: MGI:6865735
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Minpp1^em1Vca/Minpp1^em1Vca	C57BL/6J-Minpp1^em1Vca	MGI:6865737

Genotype
MGI:6865737

hm1

• Allelic Composition: Minpp1^em1Vca/Minpp1^em1Vca
• Genetic Background: C57BL/6J-Minpp1^em1Vca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased brain weight ( J:299426 )

• mild, but significant, approximate 10% decrease in brain weight associated with a reduced cortical thickness at P21

thin cerebral cortex ( J:299426 )

• cortical thickness is reduced at P21

• however, mice are fertile and are born at Mendelian ratios, and no major differences in cerebellar or cerebral cortex architecture are seen

abnormal neuron physiology ( J:299426 )

• 33.6% decrease in intracellular free calcium levels in neural progenitors at E14.5