Phenotypes associated with this allele

• Allele Symbol: Pwwp2b^tm1.1Bcgen
• Allele Name: targeted mutation 1.1, Biocytogen LLC
• Allele ID: MGI:6867219
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pwwp2b^tm1.1Bcgen/Pwwp2b^tm1.1Bcgen Tg(Adipoq-cre)1Evdr/0	involves: C57BL/6 * FVB/NJ	MGI:6867797

Genotype
MGI:6867797

cn1

• Allelic Composition: Pwwp2b^tm1.1Bcgen/Pwwp2b^tm1.1Bcgen; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: C57BL/6 * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal adaptive thermogenesis ( J:319940 )

• enhanced adaptive thermogenesis with increased temperature following cold exposure compared with control mice

increased oxygen consumption ( J:319940 )

• at night in mice fed a high-fat diet compared with control mice

• however, carbon dioxide production is normal

improved glucose tolerance ( J:319940 )

• in mice fed a high-fat diet compared with control mice

increased insulin sensitivity ( J:319940 )

• in mice fed a high-fat diet compared with control mice

increased basal metabolism ( J:319940 )

• in mice fed a high-fat diet compared with control mice

adipose tissue

decreased body fat mass ( J:319940 )

• in mice fed a high-fat diet compared with control mice

decreased brown fat cell lipid droplet size ( J:319940 )

• in mice fed a high-fat diet compared with control mice

whitened brown adipose tissue morphology ( J:319940 )

decreased white fat cell lipid droplet size ( J:319940 )

• in mice fed a high-fat diet compared with control mice

decreased inguinal fat pad weight ( J:319940 )

• in mice fed a high-fat diet compared with control mice

growth/size/body

decreased body fat mass ( J:319940 )

• in mice fed a high-fat diet compared with control mice

decreased susceptibility to weight gain ( J:319940 )

• in mice fed a high-fat diet compared with control mice

liver/biliary system

abnormal liver morphology ( J:319940 )

• fewer vacuoles in the liver of mice fed a high-fat diet compared with control mice

respiratory system

decreased pulmonary respiratory rate ( J:319940 )

• during the day and night in mice fed a high-fat diet compared with control mice