Phenotypes associated with this allele

• Allele Symbol: Igdcc4^em1Bcgen
• Allele Name: endonuclease-mediated mutation 1, Biocytogen LLC
• Allele ID: MGI:6867809
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igdcc4^em1Bcgen/Igdcc4^em1Bcgen	involves: C57BL/6J	MGI:6867811

Genotype
MGI:6867811

hm1

• Allelic Composition: Igdcc4^em1Bcgen/Igdcc4^em1Bcgen
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:320015 )

• following H5N1 infection 5 mice died between days 8 and 12 days post infection but the other 5 survived, in contrast all similarly infected wild-type controls died between 8 and 11 days post infection

immune system

decreased susceptibility to Orthomyxoviridae infection ( J:320015 )

• H5N1 viral titers in the nasal turbinates and lungs are significantly lower compared to similarly infected wild-type controls

• following infection with H5N1 mice lose less than 10% of their body weight unlike similarly infected wild-type controls

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:320015 )

• following H5N1 infection 5 mice died between days 8 and 12 days post infection but the other 5 survived, in contrast all similarly infected wild-type controls died between 8 and 11 days post infection