Phenotypes associated with this allele

• Allele Symbol: Loxl4^em1Bcgen
• Allele Name: endonuclease-mediated mutation 1, Biocytogen LLC
• Allele ID: MGI:6867825
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Loxl4^em1Bcgen/Loxl4^em1Bcgen	involves: C57BL/6J	MGI:7408061

Genotype
MGI:7408061

hm1

• Allelic Composition: Loxl4^em1Bcgen/Loxl4^em1Bcgen
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:319500 )

N • mice do not spontaneously develop aortic aneurysms up to the age of 12 months

N • after subcutaneous angiotensin II infusion, 20-week-old male mice show a comparable incidence of thoracic and abdominal aortic aneurysms with no significant differences in blood pressure elevations, arterial stiffness (as measured by aortic pulse wave velocity) or aortic lumen diameters relative to angiotensin II-infused wild-type controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:319500 )

N • mice exhibit normal lysyl oxidase enzyme activity in the heart and aorta tissues