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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrrc23em2Mngx
endonuclease-mediated mutation 2, Mingxi Liu
MGI:6877115
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lrrc23em2Mngx/Lrrc23em2Mngx involves: C57BL/6 * DBA/2 MGI:6879435


Genotype
MGI:6879435
hm1
Allelic
Composition		 Lrrc23em2Mngx/Lrrc23em2Mngx
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc23em2Mngx mutation (0 available); any Lrrc23 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm radial spoke morphology ( J:320661 )
• spermatozoa show partial radial spoke absence
asthenozoospermia ( J:320661 )
• reduction in sperm motility and progressive movement
male infertility ( J:320661 )
• males are infertile
• however, no differences in testis weight, sperm counts, or sperm morphology are seen

cellular
abnormal sperm radial spoke morphology ( J:320661 )
• spermatozoa show partial radial spoke absence
asthenozoospermia ( J:320661 )
• reduction in sperm motility and progressive movement




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory