Analysis Tools|
Allele Symbol Allele Name Allele ID |
Palmtm1.2Kili targeted mutation 1.2, Manfred W Kilimann MGI:6883588 |
||||||||||||||||
| Summary |
3 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice are healthy, fertile and overtly normal and show normal development of the lymphatic network in the tail and intestinal villi after birth; adult mice exhibit normal lymphatic vessel structure and physiological function with no signs of lymphedema
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 12-week-old mice show a significant decrease in the Lyve-1+ lymphatic coverage of pancreatic tumors relative to double transgenic mice that are wild-type for Palm, indicating impaired tumor-associated lymphangiogenesis
• however, no changes in the number of pancreatic tumors, tumor volume, or intratumoral CD31+ blood microvessel density are observed relative to double transgenic mice wild-type for Palm
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 4-week-old mice show an increase in peri-insular lymphangiogenesis and Lyve-1+ lymphatic vessel density in the periphery of islets of Langerhans that is comparable to that seen in non-tumorigenic Tg(Ins2-VEGFC)#Pepr transgenic mice, consistent with de novo lymphangiogenesis
• however, no increase in CD31+ blood microvessel density is observed within islets, similar to Tg(Ins2-VEGFC)#Pepr mice, suggesting normal angiogenesis
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/05/2024 MGI 6.24 |
|
|
|
||
