Phenotypes associated with this allele

• Allele Symbol: Rps2^tm1.1Geno
• Allele Name: targeted mutation 1.1, Genoway
• Allele ID: MGI:6883670
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rps2^tm1.1Geno/Rps2^tm1.1Geno	B6.129(Cg)-Rps2^tm1.1Geno	MGI:6883699
ht2	Rps2^tm1.1Geno/Rps2^+	B6.129(Cg)-Rps2^tm1.1Geno	MGI:6883700

Genotype
MGI:6883699

hm1

• Allelic Composition: Rps2^tm1.1Geno/Rps2^tm1.1Geno
• Genetic Background: B6.129(Cg)-Rps2^tm1.1Geno

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:321029 )

• no mice are produced

Genotype
MGI:6883700

ht2

• Allelic Composition: Rps2^tm1.1Geno/Rps2⁺
• Genetic Background: B6.129(Cg)-Rps2^tm1.1Geno

growth/size/body

decreased body weight ( J:321029 )

homeostasis/metabolism

increased circulating creatine kinase level ( J:321029 )

adipose tissue

decreased total body fat amount ( J:321029 )

behavior/neurological

behavior/neurological phenotype ( J:321029 )

N • mice exhibit normal learning, memory, locomotor activity, exploration, and anxiety-related responses

decreased grip strength ( J:321029 )

weakness ( J:321029 )

• mild without fiber atrophy or fiber-type switching

cellular

oxidative stress ( J:321029 )

• increased reactive oxygen species metabolites