Phenotypes associated with this allele

• Allele Symbol: Dnhd1^em1Glin
• Allele Name: endonuclease-mediated mutation 1, Ge Lin
• Allele ID: MGI:6885589
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnhd1^em1Glin/Dnhd1^em1Glin	C57BL/6-Dnhd1^em1Glin	MGI:6885591

Genotype
MGI:6885591

hm1

• Allelic Composition: Dnhd1^em1Glin/Dnhd1^em1Glin
• Genetic Background: C57BL/6-Dnhd1^em1Glin

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm flagellum morphology ( J:321189 )

• more than 95% of sperm show abnormalities of sperm flagella, including coiled flagella (39.4%), bent caliber (21.9%), short flagella (5.5%) and irregular flagella (5.5%)

• however, sperm head shows no differences in morphology

coiled sperm flagellum ( J:321189 )

• 34.4% of sperm show coiled flagella

hairpin sperm flagellum ( J:321189 )

• 21.9% of sperm show bent caliber forming hairpin loops

short sperm flagellum ( J:321189 )

• 5.5% of sperm show short flagella

oligozoospermia ( J:321189 )

• sperm concentration is reduced

decreased sperm progressive motility ( J:321189 )

• sperm progressive motility is decreased

asthenozoospermia ( J:321189 )

• sperm motility rate is decreased

male infertility ( J:321189 )

• males mated with wild-type females have an average of 0 offspring per litter during a 3-month reproductive period

• however, size or weight of testes is unaffected

impaired fertilization ( J:321189 )

• in vitro fertilization (IVF) using caudal epididymal sperm to fertilize oocytes indicates fewer rates of two-cell embryos and blastocyst

• however, intracytoplasmic sperm injection into wild-type oocytes results in successful fertilization of oocytes in IVF

cellular

abnormal sperm flagellum morphology ( J:321189 )

• more than 95% of sperm show abnormalities of sperm flagella, including coiled flagella (39.4%), bent caliber (21.9%), short flagella (5.5%) and irregular flagella (5.5%)

• however, sperm head shows no differences in morphology

coiled sperm flagellum ( J:321189 )

• 34.4% of sperm show coiled flagella

hairpin sperm flagellum ( J:321189 )

• 21.9% of sperm show bent caliber forming hairpin loops

short sperm flagellum ( J:321189 )

• 5.5% of sperm show short flagella

oligozoospermia ( J:321189 )

• sperm concentration is reduced

decreased sperm progressive motility ( J:321189 )

• sperm progressive motility is decreased

asthenozoospermia ( J:321189 )

• sperm motility rate is decreased