Phenotypes associated with this allele

• Allele Symbol: Btnl2^em1Wche
• Allele Name: endonuclease-mediated mutation 1, Chenhui Wang
• Allele ID: MGI:6885845
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Btnl2^em1Wche/Btnl2^em1Wche	C57BL/6-Btnl2^em1Wche	MGI:6885854

Genotype
MGI:6885854

hm1

• Allelic Composition: Btnl2^em1Wche/Btnl2^em1Wche
• Genetic Background: C57BL/6-Btnl2^em1Wche

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal crypts of Lieberkuhn morphology ( J:321348 )

• loss of colonic crypt architecture

large intestinal inflammation ( J:321348 )

• large bowel inflammation

endocrine/exocrine glands

abnormal crypts of Lieberkuhn morphology ( J:321348 )

• loss of colonic crypt architecture

hematopoietic system

abnormal gamma-delta T cell morphology ( J:321348 )

• decrease in gamma-delta T17 cells in the intestinal epithelial lymphocyte population

• however, the IFN-gamma-producing gamma-delta T cell population is unchanged

homeostasis/metabolism

abnormal cytokine level ( J:321348 )

• expression of pro-inflammatory cytokines, including TNF-alpha and IL-1beta, are increased in colonic tissue

immune system

large intestinal inflammation ( J:321348 )

• large bowel inflammation

abnormal gamma-delta T cell morphology ( J:321348 )

• decrease in gamma-delta T17 cells in the intestinal epithelial lymphocyte population

• however, the IFN-gamma-producing gamma-delta T cell population is unchanged

abnormal cytokine level ( J:321348 )

• expression of pro-inflammatory cytokines, including TNF-alpha and IL-1beta, are increased in colonic tissue

neoplasm

neoplasm ( J:321348 )

N • wild-type Lewis lung cancer (LLC) tumors show attenuated growth in mutant mice, but not significantly