All Phenotypes Prickle1<em1Yzou> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prickle1^em1Yzou/Prickle1^em1Yzou	C57BL/6-Prickle1^em1Yzou	MGI:6890373
ht2	Prickle1^em1Yzou/Prickle1⁺	C57BL/6-Prickle1^em1Yzou	MGI:6890374

Allelic Composition	Prickle1^em1Yzou/Prickle1^em1Yzou
Genetic Background	C57BL/6-Prickle1^em1Yzou

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prickle1^em1Yzou mutation (0 available); any Prickle1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal object recognition memory ( J:321396 )

• in the novel object recognition task, mice do not display strong preference to the novel object as shown by lower discrimination index, indicating impaired novel object recognition

• however, mice show no differences from wild-type mice in spatial memory

abnormal social investigation ( J:321396 )

• mice show deficits in sociability in the three-chamber social interaction task, spending less time engaging in social behavior

• however, mice show normal social recognition memory in the three-chamber social novelty task

• mice show no differences in anxiety in the open field arena, elevated plus maze, or light-dark transition tasks

nervous system

abnormal excitatory synapse morphology ( J:321396 )

• mice show a 20% reduction in the number of excitatory glutamatergic synapses in the hippocampus at P14 and 35% reduction in adults

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:321396

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:321396 )

• mice exhibit shorter latencies to Pentylenetrazole (PTZ)-induced tonic-clonic seizure indicating reduced seizure threshold

• seizure susceptibility is enhanced more than in homozygous mice

abnormal spatial reference memory ( J:321396 )

• in the Barnes maze task, mice spend similar time in the target quadrant and other quadrants unlike controls that spend more time in the target quadrant, indicating a mild deficit in spatial memory

• however, mice show no differences from wild-type mice in novel object recognition