Phenotypes associated with this allele

• Allele Symbol: Ppic^em1Igc
• Allele Name: endonuclease-mediated mutation 1, Instituto Gulbenkian de Ciencia
• Allele ID: MGI:6886012
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppic^em1Igc/Ppic^em1Igc	C57BL/6-Ppic^em1Igc	MGI:6886063

Genotype
MGI:6886063

hm1

• Allelic Composition: Ppic^em1Igc/Ppic^em1Igc
• Genetic Background: C57BL/6-Ppic^em1Igc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased transitional stage T1 B cell number ( J:321155 )

increased transitional stage T2 B cell number ( J:321155 )

decreased NK cell number ( J:321155 )

• reduced invariant NK T cells with reduced later stage differentiation S2 and S3 cells

• however, early stage S0 and S1 cell numbers are normal

hematopoietic system

hematopoietic system phenotype ( J:321155 )

N • mice exhibit normal hematopoietic progenitors in the bone marrow and alpha-beta or gamma-delta T lymphocyte differentiation

increased transitional stage T1 B cell number ( J:321155 )

increased transitional stage T2 B cell number ( J:321155 )

decreased NK cell number ( J:321155 )

• reduced invariant NK T cells with reduced later stage differentiation S2 and S3 cells

• however, early stage S0 and S1 cell numbers are normal