Analysis Tools
adipose tissue
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• in mice fed a high-fat diet at room temperature
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• in 10-week old mice
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• defective beige fat thermogenesis
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• reduced [18F] fluorodeoxyglucose uptake in mice fed a high-fat diet indicating reduced thermogenic brown adipose tissue
• mice treated with NE fail to exhibit an increase in oxygen consumption in brown adipose tissue unlike in wild-type tissues
• however, uptake in white adipose tissue is normal
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• impaired
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homeostasis/metabolism
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• mice exhibit normal energy expenditure or energy intake when housed at 22 Celsius
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• blunted temperature response to norepinephrine treatment
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• after cold-exposure, mice exhibit difficulty maintaining core body temperature compared with wild-type mice
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• in newborn mice
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• lower baseline energy expenditure in mice fed a high-fat diet at room temperature
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• mice fed a high-fat diet at room temperature exhibit accelerated weight gain compared with similarly treated wild-type mice
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• mice treated with NE fail to exhibit an increase in oxygen consumption in brown adipose tissue unlike in wild-type tissues
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• in mice fed a high-fat diet at room temperature
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• in mice fed a high-fat diet at room temperature
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growth/size/body
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• in mice fed a high-fat diet at room temperature
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• mice fed a high-fat diet at room temperature exhibit accelerated weight gain compared with similarly treated wild-type mice
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• in mice fed a high-fat diet
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liver/biliary system
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• in mice fed a high-fat diet
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• in mice fed a high-fat diet
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