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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
C2cd3em2Brgm
endonuclease-mediated mutation 2, Samantha A Brugmann
MGI:6887618
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
C2cd3em2Brgm/C2cd3em2Brgm
E2f1Tg(Wnt1-cre)2Sor/E2f1+
involves: C3H * C57BL/6 MGI:6887946


Genotype
MGI:6887946
cn1
Allelic
Composition
C2cd3em2Brgm/C2cd3em2Brgm
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C2cd3em2Brgm mutation (0 available); any C2cd3 mutation (101 available)
E2f1Tg(Wnt1-cre)2Sor mutation (2 available); any E2f1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• dysmorphic tongue

cellular
• increased Gli3FL/Gli3R ratio indicating the cilia are functionally impaired

skeleton
• delayed ossification of the palatine bone at E17.5

digestive/alimentary system
• dysmorphic tongue

growth/size/body
• dysmorphic tongue





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory