All Phenotypes C2cd3<tm1c(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

C2cd3^{tm1c(EUCOMM)Wtsi}
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6887626

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	C2cd3^{tm1c(EUCOMM)Wtsi}/C2cd3^{tm1c(EUCOMM)Wtsi} E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺	involves: C3H * C57BL/6	MGI:6887948

Allelic Composition	C2cd3^{tm1c(EUCOMM)Wtsi}/C2cd3^{tm1c(EUCOMM)Wtsi} E2f1^{Tg(Wnt1-cre)2Sor}/E2f1⁺
Genetic Background	involves: C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C2cd3^{tm1c(EUCOMM)Wtsi} mutation (0 available); any C2cd3 mutation (101 available)
E2f1^{Tg(Wnt1-cre)2Sor} mutation (2 available); any E2f1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal facial morphology ( J:308674 )

• midline widening detected at e11.5 which is exacerbated at E15.5

cleft palate ( J:308674 )

tongue hypoplasia ( J:308674 )

cellular

abnormal cilium physiology ( J:308674 )

• increased Gli3FL/Gli3R ratio indicating the cilia are functionally impaired

skeleton

delayed bone ossification ( J:308674 )

• delayed ossification of the palatine and sphenoid bones at E17.5

digestive/alimentary system

cleft palate ( J:308674 )

tongue hypoplasia ( J:308674 )

growth/size/body

abnormal facial morphology ( J:308674 )

• midline widening detected at e11.5 which is exacerbated at E15.5

cleft palate ( J:308674 )

tongue hypoplasia ( J:308674 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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