Phenotypes associated with this allele

• Allele Symbol: Neu2^em1Kyp
• Allele Name: endonuclease-mediated mutation 1, Kyoungsook Park
• Allele ID: MGI:6887912
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Neu2^em1Kyp/Neu2^em1Kyp	C57BL/6J-Neu2^em1Kyp	MGI:6887939

Genotype
MGI:6887939

hm1

• Allelic Composition: Neu2^em1Kyp/Neu2^em1Kyp
• Genetic Background: C57BL/6J-Neu2^em1Kyp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired exercise endurance ( J:321653 )

• adult and elderly mice show decreased rotarod exercise performance; motor performance is decreased by 42.2 s in adults and 69.3 s in elderly mice

• rotarod motor performance is decreased with increasing age with maximum deficiency in the elderly group

• in the treadmill exercise performance test, adult and elderly mice show a slighter shorter distance traveled

increased blood urea nitrogen level ( J:321653 )

increased circulating cholesterol level ( J:321653 )

• level of blood total cholesterol is elevated

increased circulating free fatty acids level ( J:321653 )

• serum free fatty acid concentration is increased 1.7-fold in adult (23-25 weeks of age) mice

increased circulating triglyceride level ( J:321653 )

• concentration of serum triglycerides is increased at 9-10 weeks of age and 23-25 weeks of age

abnormal energy homeostasis ( J:321653 )

• energy consumption of elderly mice in the dark condition is decreased by up to 21%

decreased energy expenditure ( J:321653 )

• adult and elderly mice exhibit lower energy expenditure during both day and night

• energy expenditure rate is reduced in adults and further reduced in elder mice

decreased carbon dioxide production ( J:321653 )

• elderly mice exhibit low carbon dioxide production

decreased oxygen consumption ( J:321653 )

• elderly mice exhibit low oxygen consumption

increased liver free fatty acids level ( J:321653 )

• free fatty acid level in liver is increased by 1.9-fold in elderly (41-55 weeks of age) mice

increased muscle free fatty acids level ( J:321653 )

• increase in free fatty acid level in EDL muscle

liver/biliary system

increased liver free fatty acids level ( J:321653 )

• free fatty acid level in liver is increased by 1.9-fold in elderly (41-55 weeks of age) mice

hepatic steatosis ( J:321653 )

• increase in lipid droplets and lipid accumulation in the liver of elderly mice

• elderly mice over 41 weeks of age exhibit severe liver steatosis

• however, hepatic steatosis is not seen at 25 weeks or earlier

liver fibrosis ( J:321653 )

• liver fibrosis is seen in areas of hepatic steatosis

• however, hepatic fibrosis is not seen at 25 weeks or earlier

muscle

increased muscle free fatty acids level ( J:321653 )

• increase in free fatty acid level in EDL muscle

abnormal muscle morphology ( J:321653 )

• greater than 5.7-fold increase in the perimysium area of extensor digitorum longus (EDL) muscle of 25-week-old mice

• marker analysis indicates impaired muscle differentiation

decreased skeletal muscle fiber number ( J:321653 )

• 30% decrease in EDL muscle myofibers in 25-week-old mice

behavior/neurological

abnormal motor learning ( J:321653 )

• in a forced rotarod exercise paradigm, motor learning ability during consecutive experimental days does not improve in mutant mice compared to wild-type littermates indicating that exercise learning ability is affected

impaired exercise endurance ( J:321653 )

• adult and elderly mice show decreased rotarod exercise performance; motor performance is decreased by 42.2 s in adults and 69.3 s in elderly mice

• rotarod motor performance is decreased with increasing age with maximum deficiency in the elderly group

• in the treadmill exercise performance test, adult and elderly mice show a slighter shorter distance traveled

growth/size/body

increased body weight ( J:321653 )

• body weights gradually change over 10 weeks from weeks 6 to 16, with elderly mice showing a greater than 1.3-fold increase in body weight

obese ( J:321653 )

• elderly mice are obese