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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tubb4atm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:6887962
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tubb4aJit/Tubb4atm1c(EUCOMM)Hmgu
Tg(Atoh1-cre)1Bfri/0 		involves: C57BL/6 * C57BL/6N * CBA * FVB/N MGI:6888390
cn2
 		Ifi208Tg(Cspg4-cre)1Akik/Ifi208+
Tubb4aJit/Tubb4atm1c(EUCOMM)Hmgu 		involves: C57BL/6 * C57BL/6N * FVB/N * SJL MGI:6888389


Genotype
MGI:6888390
cn1
Allelic
Composition		 Tubb4aJit/Tubb4atm1c(EUCOMM)Hmgu
Tg(Atoh1-cre)1Bfri/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Atoh1-cre)1Bfri mutation (1 available)
Tubb4aJit mutation (0 available); any Tubb4a mutation (30 available)
Tubb4atm1c(EUCOMM)Hmgu mutation (0 available); any Tubb4a mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cerebellar granule cell morphology ( J:321692 )
• loss of granule cell neurons
• however, no reduction of myelination levels is seen




Genotype
MGI:6888389
cn2
Allelic
Composition		 Ifi208Tg(Cspg4-cre)1Akik/Ifi208+
Tubb4aJit/Tubb4atm1c(EUCOMM)Hmgu
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifi208Tg(Cspg4-cre)1Akik mutation (1 available); any Ifi208 mutation (36 available)
Tubb4aJit mutation (0 available); any Tubb4a mutation (30 available)
Tubb4atm1c(EUCOMM)Hmgu mutation (0 available); any Tubb4a mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
dysmyelination ( J:321692 )
• reduction of myelination in the hindbrain




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory