About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm1.1(CAG-YFP/DROSHA*E1147K)Gess
targeted mutation 1.1, Manfred Gessler
MGI:6887963
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1.1(CAG-YFP/DROSHA*E1147K)Gess/Gt(ROSA)26Sortm1.1(CAG-YFP/DROSHA*E1147K)Gess
Tg(Six2-EGFP/cre)1Amc/0
involves: 129S6/SvEvTac * C57BL/6 * CD-1 MGI:6887991


Genotype
MGI:6887991
cn1
Allelic
Composition
Gt(ROSA)26Sortm1.1(CAG-YFP/DROSHA*E1147K)Gess/Gt(ROSA)26Sortm1.1(CAG-YFP/DROSHA*E1147K)Gess
Tg(Six2-EGFP/cre)1Amc/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.1(CAG-YFP/DROSHA*E1147K)Gess mutation (0 available); any Gt(ROSA)26Sor mutation (992 available)
Tg(Six2-EGFP/cre)1Amc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• increased apoptosis of epithelial cells and in nephrogenic zone

growth/size/body
• severe growth retardation

homeostasis/metabolism
• extensive protein deposits in kidney tubules by age P28

renal/urinary system
• increased apoptosis of epithelial cells and in nephrogenic zone
• extensive protein deposits in kidney tubules by age P28
• increasing with age
• reduced and patchy Six2, absent Sited1 and early loss of Wt1 expression in E16.5 embryos
• smaller kidneys
• severely impaired tubular maturation
• at least one absent kidney in 23% of E16.5 embryos, both absent in 1.8%

mortality/aging
N
• viable; survive from 38 to 283 days

neoplasm
N
• no kidney tumor development in mice up to 283 days old





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory