cellular
• increased apoptosis of epithelial cells and in nephrogenic zone
|
growth/size/body
• severe growth retardation
|
homeostasis/metabolism
• extensive protein deposits in kidney tubules by age P28
|
renal/urinary system
• increased apoptosis of epithelial cells and in nephrogenic zone
|
• extensive protein deposits in kidney tubules by age P28
|
• increasing with age
|
• reduced and patchy Six2, absent Sited1 and early loss of Wt1 expression in E16.5 embryos
|
• smaller kidneys
|
• severely impaired tubular maturation
|
• at least one absent kidney in 23% of E16.5 embryos, both absent in 1.8%
|
mortality/aging
N |
• viable; survive from 38 to 283 days
|
neoplasm