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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm1.1(CAG-YFP/DROSHA*E1147K)Gess
targeted mutation 1.1, Manfred Gessler
MGI:6887963
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm1.1(CAG-YFP/DROSHA*E1147K)Gess/Gt(ROSA)26Sortm1.1(CAG-YFP/DROSHA*E1147K)Gess
Tg(Six2-EGFP/cre)1Amc/0
involves: 129S6/SvEvTac * C57BL/6 * CD-1 MGI:6887991


Genotype
MGI:6887991
cn1
Allelic
Composition
Gt(ROSA)26Sortm1.1(CAG-YFP/DROSHA*E1147K)Gess/Gt(ROSA)26Sortm1.1(CAG-YFP/DROSHA*E1147K)Gess
Tg(Six2-EGFP/cre)1Amc/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.1(CAG-YFP/DROSHA*E1147K)Gess mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Six2-EGFP/cre)1Amc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• increased apoptosis of epithelial cells and in nephrogenic zone

growth/size/body
• severe growth retardation

homeostasis/metabolism
• extensive protein deposits in kidney tubules by age P28

renal/urinary system
• increased apoptosis of epithelial cells and in nephrogenic zone
• extensive protein deposits in kidney tubules by age P28
• increasing with age
• reduced and patchy Six2, absent Sited1 and early loss of Wt1 expression in E16.5 embryos
• smaller kidneys
• severely impaired tubular maturation
• at least one absent kidney in 23% of E16.5 embryos, both absent in 1.8%

mortality/aging
N
• viable; survive from 38 to 283 days

neoplasm
N
• no kidney tumor development in mice up to 283 days old





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory