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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rab7btm1Ciphe
targeted mutation 1, Centre d'ImmunoPhenomique
MGI:6888140
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rab7btm1Ciphe/Rab7btm1Ciphe
Tg(Itgax-cre)1-1Reiz/0 		involves: C57BL/6N * CBA MGI:6888148


Genotype
MGI:6888148
cn1
Allelic
Composition		 Rab7btm1Ciphe/Rab7btm1Ciphe
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab7btm1Ciphe mutation (0 available); any Rab7b mutation (20 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell migration ( J:321707 )
• decreased migration speed in LPS-exposed cells

hematopoietic system
abnormal dendritic cell migration ( J:321707 )
• decreased migration speed in LPS-exposed cells

cellular
abnormal lysosome morphology ( J:321707 )
• reduced number of small lysosomes per cell in LPS-exposed cells
abnormal dendritic cell migration ( J:321707 )
• decreased migration speed in LPS-exposed cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory