Phenotypes associated with this allele

• Allele Symbol: Clptm1^em1(IMPC)Tcp
• Allele Name: endonuclease-mediated mutation 1, The Centre for Phenogenomics
• Allele ID: MGI:7256882
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clptm1^em1(IMPC)Tcp/Clptm1^em1(IMPC)Tcp	C57BL/6N-Clptm1^em1(IMPC)Tcp/Cmmr	MGI:7414840
ht2	Clptm1^em1(IMPC)Tcp/Clptm1^+	C57BL/6N-Clptm1^em1(IMPC)Tcp/Cmmr	MGI:7414839

Genotype
MGI:7414840

hm1

• Allelic Composition: Clptm1^em1(IMPC)Tcp/Clptm1^em1(IMPC)Tcp
• Genetic Background: C57BL/6N-Clptm1^em1(IMPC)Tcp/Cmmr

Data Sources

IMPC Data for Clptm1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Clptm1^em1(IMPC)Tcp/Clptm1^em1(IMPC)Tcp mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as dying morulas. Mutants fail to hatch from the zona pellucida and are dead after 3 days in culture.

embryo

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro outgrowth assays show that embryos fail to hatch from the zona pellucida after 3 days in culture

abnormal morula morphology ( J:279207 )

• embryos recovered at E3.5 appear as dying morulae

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - TCP

preweaning lethality, complete penetrance ( J:211773 )

IMPC - TCP

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are present in expected Mendelian ratios at E3.5 and appear as dying morulae; no homozygous embryos or excess resorption sites are observed at E7.5

reproductive system

failure of embryo implantation ( J:279207 )

• in vitro, embryos fail to hatch and are dead after 3 days in culture, never forming outgrowths

Genotype
MGI:7414839

ht2

• Allelic Composition: Clptm1^em1(IMPC)Tcp/Clptm1⁺
• Genetic Background: C57BL/6N-Clptm1^em1(IMPC)Tcp/Cmmr

Data Sources

IMPC Data for Clptm1

behavior/neurological

decreased exploration in new environment ( J:211773 )

♂

IMPC - TCP

increased anxiety-related response ( J:211773 )

♂

IMPC - TCP

decreased locomotor activity ( J:211773 )

♂

IMPC - TCP

hematopoietic system

decreased hematocrit ( J:211773 )

♀

IMPC - TCP

decreased mean corpuscular hemoglobin ( J:211773 )

IMPC - TCP

increased mean corpuscular hemoglobin concentration ( J:211773 )

IMPC - TCP

decreased mean corpuscular volume ( J:211773 )

IMPC - TCP

increased monocyte cell number ( J:211773 )

♂

IMPC - TCP

immune system

increased monocyte cell number ( J:211773 )

♂

IMPC - TCP

enlarged lymph nodes ( J:211773 )

♂

IMPC - TCP

integument

abnormal skin morphology ( J:211773 )

♂

IMPC - TCP