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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Yars1tm1.1Rwb
targeted mutation 1.1, Robert W Burgess
MGI:7257843
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Yars1tm1.1Rwb/Yars1tm1.1Rwb involves: C57BL/6N * FVB/N MGI:7258133


Genotype
MGI:7258133
hm1
Allelic
Composition		 Yars1tm1.1Rwb/Yars1tm1.1Rwb
Genetic
Background		 involves: C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yars1tm1.1Rwb mutation (0 available); any Yars1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal DNA-templated transcription ( J:310162 )
• induction of integrated stress response (ISR) in alpha motor neurons and whole spinal cord: upregulation of transcription of cellular stress-related genes at age 7 months

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Charcot-Marie-Tooth disease dominant intermediate C DOID:0110199 OMIM:608323
 J:310162




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory