Phenotypes associated with this allele

• Allele Symbol: Ndnf^em1Nou
• Allele Name: endonuclease-mediated mutation 1, Noriyuki Ouchi
• Allele ID: MGI:7259868
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ndnf^em1Nou/Ndnf^em1Nou	C57BL/6J-Ndnf^em1Nou	MGI:7259894

Genotype
MGI:7259894

hm1

• Allelic Composition: Ndnf^em1Nou/Ndnf^em1Nou
• Genetic Background: C57BL/6J-Ndnf^em1Nou

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

skeletal muscle atrophy ( J:322617 )

• mice exhibit enhanced skeletal muscle atrophy in dexamethasone infusion and sciatic denervation models of muscle atrophy

• however, mice show no differences in body weight, tissue weights or white adipose tissue, gastrocnemius muscle, liver, heart, and lung, and fasting blood sugar at 10 weeks of age

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:322617 )

• mice treated with dexamethasone (DEX) to induce muscle atrophy show a lower gastrocnemius muscle weight and smaller cross-sectional areas of gastrocnemius muscle fibers than wild-type mice at 14 days after continuous DEX injection indicating enhanced induced skeletal muscle atrophy

• administration of NDNF attenuates skeletal muscle atrophy induced by DEX

increased susceptibility to injury ( J:322617 )

• mice subjected to a denervation-induced muscle atrophy show lower denervated gastrocnemius muscle weights and reduced cross-sectional areas of muscle fibers at 5 days after removal of the sciatic nerve compared to wild-type mice

• administration of NDNF attenuates skeletal muscle atrophy induced by sciatic denervation