Phenotypes associated with this allele

• Allele Symbol: Tmc4^em1Abek
• Allele Name: endonuclease-mediated mutation 1, Keiko Abe
• Allele ID: MGI:7259873
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmc4^em1Abek/Tmc4^em1Abek	C57BL/6J-Tmc4^em1Abek	MGI:7259879

Genotype
MGI:7259879

hm1

• Allelic Composition: Tmc4^em1Abek/Tmc4^em1Abek
• Genetic Background: C57BL/6J-Tmc4^em1Abek

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

taste/olfaction

abnormal gustatory system physiology ( J:322396 )

• decreased glossopharyngeal nerve response to 100 mM and 300 mM NaCl

• however, response in the chorda tympani nerve is normal and response to 300 mM NaCl containing 30 uM amiloride is normal

abnormal salty taste sensitivity ( J:322396 )

• increased lick ration compared with wild-type mice

• however, mice exhibit normal licking behavior toward KCl, sucrose, denatonium, MSG and 0.5 mM IMP, citrici acid, and NaCl when treated with furosemide and a low sodium diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:322396 )

N • mice exhibit normal urine levels of Na, K, Cl, Ca, and Mg