All Phenotypes Samd3<tm1.1(HBEGF)Wfkr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Samd3^{tm1.1(HBEGF)Wfkr}
targeted mutation 1.1, Wolfgang Kastenmeuller
MGI:7260138

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Samd3^{tm1.1(HBEGF)Wfkr}/Samd3^{tm1.1(HBEGF)Wfkr}	C57BL/6J-Samd3^{tm1.1(HBEGF)Wfkr}	MGI:7261152
ht2	Samd3^{tm1.1(HBEGF)Wfkr}/Samd3⁺	C57BL/6J-Samd3^{tm1.1(HBEGF)Wfkr}	MGI:7261153

Allelic Composition	Samd3^{tm1.1(HBEGF)Wfkr}/Samd3^{tm1.1(HBEGF)Wfkr}
Genetic Background	C57BL/6J-Samd3^{tm1.1(HBEGF)Wfkr}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Samd3^{tm1.1(HBEGF)Wfkr} mutation (0 available); any Samd3 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:322359 )

N	• mice exhibit normal response to acute Vaccinia virus or chronic Lymphocytic choriomeningitis virus infection

decreased CD8-positive, alpha-beta memory T cell number ( J:322359 )

• reduced relative and absolute numbers in mice infected with Vaccinia virus expressing ovalbumin

• however, differentiation and survival of CD8+ memory cells is normal

hematopoietic system

decreased CD8-positive, alpha-beta memory T cell number ( J:322359 )

• reduced relative and absolute numbers in mice infected with Vaccinia virus expressing ovalbumin

• however, differentiation and survival of CD8+ memory cells is normal

Allelic Composition	Samd3^{tm1.1(HBEGF)Wfkr}/Samd3⁺
Genetic Background	C57BL/6J-Samd3^{tm1.1(HBEGF)Wfkr}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Samd3^{tm1.1(HBEGF)Wfkr} mutation (0 available); any Samd3 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK cell differentiation ( J:322359 )

• shift toward CD11b/CD27 double positive NK cells and loss of fully differentiated CD11b single positive cells in diphtheria-treated mice

decreased NK cell number ( J:322359 )

• decreased in diphtheria-treated mice

decreased memory T cell number ( J:322359 )

• loss of CD44+ memory T cells in diphtheria-treated mice