Phenotypes associated with this allele

• Allele Symbol: Lmna^tm1.1Vde
• Allele Name: targeted mutation 1.1, Valerie Delague
• Allele ID: MGI:7260353
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmna^tm1.1Vde/Lmna^tm1.1Vde	B6.129(Cg)-Lmna^tm1.1Vde	MGI:7260355

Genotype
MGI:7260355

hm1

• Allelic Composition: Lmna^tm1.1Vde/Lmna^tm1.1Vde
• Genetic Background: B6.129(Cg)-Lmna^tm1.1Vde

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

enhanced exercise endurance ( J:322912 )

• during the training stage of the treadmill test, mutant mice exhibit a stable performance at 6 and 12 months of age compared to controls which show decreased performance at 6 months

• during the fatigability stage of the treadmill test, mutant mice spend less time on the electrified grid than wild-type mice at 6 months of age

muscle

abnormal muscle tone ( J:322912 )

• 1-month-old mice show an increase in muscle tone

• however, no differences in grip test are seen in 1-18 month old mice and no muscle abnormalities are seen

behavior/neurological

behavior/neurological phenotype ( J:322912 )

N • behavior/neurological phenotype MP:0005386 mice do not show a difference on the rotarod and tail flick experiments show normal pain sensation

nervous system

nervous system phenotype ( J:322912 )

N • sciatic nerves in 18-month-old mice appear normal, nerve conduction velocities and action potential amplitudes in sciatic nerves are normal, and no signs of peripheral neuropathy are seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Charcot-Marie-Tooth disease type 2B1	DOID:0110156	OMIM:605588	J:322912