All Phenotypes Aqp4<tm1Gghu> MGI Mouse

decreased corpora lutea number ( J:323125 )

• at 8 weeks of age, fewer numbers of corpora lutea are present in spontaneously cycling ovaries

• 48 hours after hCG treatment, superovulated ovaries from 4-week-old females contain fewer numbers of corpora lutea than similarly treated wild-type ovaries

decreased tertiary ovarian follicle number ( J:323125 )

• at 8 weeks of age, fewer numbers of antral follicles are present in spontaneously cycling ovaries

• 48 hours after PMSG injection, superovulated ovaries from 4-week-old females contain fewer numbers of antral follicles and atretic follicles than similarly treated wild-type ovaries

• however, the number of atretic follicles is normal at 8 weeks of age

impaired ovarian folliculogenesis ( J:323125 )

• at 8 weeks of age, ovaries show a marked reduction in follicular development and maturation

• after treatment with exogenous gonadotropins, females produce fewer oocytes and show a significant decrease in the number of antral follicles and in corpora lutea formation

decreased ovary weight ( J:323125 )

• at 8 weeks of age, average ovarian weight is significantly lower than that in wild-type controls

• however, body weight and adrenal gland weight are normal

thin endometrium ( J:323125 )

• at 8 weeks of age, endometrial thickness is significantly decreased, suggesting a reduced uterine response

• 14 hours after hCG injection, uteri from 4-week-old females show significantly thinner endometria than similarly treated wild-type uteri

small uterus ( J:323125 )

• uteri from sexually mature females appear less hypertrophic than wild-type uteri

decreased uterus weight ( J:323125 )

• 14 hours after hCG injection, uteri from 4-week-old females show a significantly lower weight than similarly treated wild-type uteri

decreased superovulation rate ( J:323125 )

• after induction of superovulation by PMSG and hCG treatment, 4-week-old females produce significantly fewer oocytes than superovulated wild-type females

abnormal uterus physiology ( J:323125 )

• at 8 weeks of age, uteri from sexually mature females appear to be hyporeactive to gonadotropins

• uteri from 4-week-old females show a reduced response to superovulation induced by exogenous PMSG and hCG

reduced female fertility ( J:323125 )

• 8- to 10-week-old virgin female mice exhibit a markedly lower pregnancy rate than wild-type controls (65% vs 96%)

decreased litter size ( J:323125 )

• female mice produce a smaller litter size than wild-type controls (6.7 +/- 1.7 pups per litter vs 8.0 +/- 1.3 pups per litter)