About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdk19em1Smoc
endonuclease-mediated mutation 1, Shanghai Model Organisms Center
MGI:7261165
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cdk19em1Smoc/Cdk19em1Smoc C57BL/6J-Cdk19em1Smoc/Smoc MGI:7261168


Genotype
MGI:7261168
hm1
Allelic
Composition		 Cdk19em1Smoc/Cdk19em1Smoc
Genetic
Background		 C57BL/6J-Cdk19em1Smoc/Smoc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk19em1Smoc mutation (0 available); any Cdk19 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:322947 )
N
• mice exhibit normal numbers of total bone marrow and spleen cells, while blood cells, red blood cells, and platelets
increased hematopoietic stem cell number ( J:322947 )
• increased proportion of quiescent hematopoietic stem cells
abnormal hematopoietic stem cell physiology ( J:322947 )
• reduced colony formation ability of long-term hematopoietic stem cells
decreased hematopoietic stem cell proliferation ( J:322947 )
• increased proportion of quiescent hematopoietic stem cells
• however, treatment with Trp53 inhibitor rescues hematopoietic stem cell function

cellular
decreased hematopoietic stem cell proliferation ( J:322947 )
• increased proportion of quiescent hematopoietic stem cells
• however, treatment with Trp53 inhibitor rescues hematopoietic stem cell function




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory