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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cdk19em1Smoc
endonuclease-mediated mutation 1, Shanghai Model Organisms Center
MGI:7261165
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cdk19em1Smoc/Cdk19em1Smoc C57BL/6J-Cdk19em1Smoc/Smoc MGI:7261168


Genotype
MGI:7261168
hm1
Allelic
Composition		 Cdk19em1Smoc/Cdk19em1Smoc
Genetic
Background		 C57BL/6J-Cdk19em1Smoc/Smoc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk19em1Smoc mutation (0 available); any Cdk19 mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:322947 )
N
• mice exhibit normal numbers of total bone marrow and spleen cells, while blood cells, red blood cells, and platelets
increased hematopoietic stem cell number ( J:322947 )
• increased proportion of quiescent hematopoietic stem cells
abnormal hematopoietic stem cell physiology ( J:322947 )
• reduced colony formation ability of long-term hematopoietic stem cells
decreased hematopoietic stem cell proliferation ( J:322947 )
• increased proportion of quiescent hematopoietic stem cells
• however, treatment with Trp53 inhibitor rescues hematopoietic stem cell function

cellular
decreased hematopoietic stem cell proliferation ( J:322947 )
• increased proportion of quiescent hematopoietic stem cells
• however, treatment with Trp53 inhibitor rescues hematopoietic stem cell function




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory