Analysis Tools
cardiovascular system
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• 6- to 12-month-old mice, to a larger extent in older mice
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• severe mitochondrial structural defects including inter-mitochondrial vacuoles, cristae disorganization and blebbing, and extensive cristolysis that are more pronounced in the left ventricle
• some abnormal nuclei shape and positioning (unusually attached to the mitochondrial
• however, sarcomeres are well-aligned and organized
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• discontinuous, fragmented, and disorganized
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• 9- to 12-month-old mice
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• 6- to 12-month-old mice, to a larger extent in older mice
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• female mice are more affected than male mice
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behavior/neurological
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• male mice exhibit normal recognition and spatial memory and performance in an elevated plus maze
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• in male mice with decreased exploration in an open field
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• in male mice
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• lack of preference for the conspecific in male mice
• however, social novelty preference is normal
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nervous system
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• 3-month-old mice exhibit less compact neuropil with ultrastructural abnormalities, fewer presynaptic vesicles, fewer neurofilaments, and fragmented mitochondrial at synaptic junctions, and abnormal accumulation of membranous interconnected tubules compared with wild-type mice
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• swollen with fragmented and degenerating mitochondrial and disorganized neurofilaments in the molecular layer of 3-month-old mice
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• subtle in male mice
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homeostasis/metabolism
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• decreased dopamine turnover in the striatum
• increased dopamine turnover in the prefrontal cortex
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• in the striatum and prefrontal cortex
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muscle
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• severe mitochondrial structural defects including inter-mitochondrial vacuoles, cristae disorganization and blebbing, and extensive cristolysis that are more pronounced in the left ventricle
• some abnormal nuclei shape and positioning (unusually attached to the mitochondrial
• however, sarcomeres are well-aligned and organized
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• discontinuous, fragmented, and disorganized
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• female mice are more affected than male mice
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• severe mitochondrial defects
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• severe mitochondrial defects, especially in the soleus
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• dilated with loss of SR-mitochondrial contact sites
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pigmentation
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• in the cerebellum of 3-month-old mice
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limbs/digits/tail
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• severe mitochondrial defects
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• severe mitochondrial defects, especially in the soleus
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cellular
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• 6- to 12-month-old mice, to a larger extent in older mice
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