Phenotypes associated with this allele

• Allele Symbol: Fbxo47^em1Keish
• Allele Name: endonuclease-mediated mutation 1, Kei-ichiro Ishiguro
• Allele ID: MGI:7261293
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxo47^em1Keish/Fbxo47^em1Keish	C57BL/6N-Fbxo47^em1Keish	MGI:7261303

Genotype
MGI:7261303

hm1

• Allelic Composition: Fbxo47^em1Keish/Fbxo47^em1Keish
• Genetic Background: C57BL/6N-Fbxo47^em1Keish

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:322322 )

♀N • female mice exhibit normal fertility with no defects in ovaries and female meiosis

abnormal synaptonemal complex ( J:322322 )

♂ • prematurely disassembled in spermatocytes and defective meiotic recombination

increased male germ cell apoptosis ( J:322322 )

♂

small testis ( J:322322 )

♂

abnormal spermatogenesis ( J:322322 )

♂ • severely abolished at later stages

azoospermia ( J:322322 )

♂ • absent post-meiotic spermatids and spermatozoa in seminiferous tubules in 8-week-old mice

abnormal X-Y chromosome synaptonemal complex assembly during male meiosis ( J:322322 )

♂ • failure to form the XY body

male infertility ( J:322322 )

♂

cellular

azoospermia ( J:322322 )

♂ • absent post-meiotic spermatids and spermatozoa in seminiferous tubules in 8-week-old mice

abnormal X-Y chromosome synaptonemal complex assembly during male meiosis ( J:322322 )

♂ • failure to form the XY body

abnormal synaptonemal complex ( J:322322 )

♂ • prematurely disassembled in spermatocytes and defective meiotic recombination

increased male germ cell apoptosis ( J:322322 )

♂

endocrine/exocrine glands

small testis ( J:322322 )

♂