Phenotypes associated with this allele

• Allele Symbol: Norad^em1Cyang
• Allele Name: endonuclease-mediated mutation 1, Cao Yang
• Allele ID: MGI:7262675
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Norad^em1Cyang/Norad^em1Cyang	Not Specified	MGI:7262676

Genotype
MGI:7262676

hm1

• Allelic Composition: Norad^em1Cyang/Norad^em1Cyang
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature aging ( J:322873 )

• mice exhibit a degenerative phenotype resembling premature aging

skeleton

abnormal nucleus pulposus morphology ( J:322873 )

• 2-month-old mice show a moderate decrease in the cellularity of the nucleus pulposus

• senescence of nucleus pulposus cells

intervertebral disk degeneration ( J:322873 )

• intervertebral disc degeneration occurs at 2 months of age, as evidenced by collapsed disc space, narrowed endplates height, and a moderate decrease in the cellularity of the nucleus pulposus

kyphosis ( J:322873 )

homeostasis/metabolism

increased susceptibility to injury ( J:322873 )

• in a surgically induced intervertebral disc degeneration model established by needle puncture, mice show more severe degeneration of NPs and intervertebral discs than wild-type mice

• in the surgically induced intervertebral disc degeneration model, treatment with an adenovirus expressing an shPUM1 and shPUM2 restores the degeneration of IVD to some extent