Phenotypes associated with this allele

• Allele Symbol: Tg(KRT18*R89C)22Rgo
• Allele Name: transgene insertion 22, Robert G Oshima
• Allele ID: MGI:7262689
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(KRT18*R89C)22Rgo/0	involves: FVB/N	MGI:7262692

Genotype
MGI:7262692

tg1

• Allelic Composition: Tg(KRT18*R89C)22Rgo/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

abnormal liver vasculature morphology ( J:241700 )

• livers show increased prominence of the vascular subcapsular markings, with appearance of a punctate pattern rather than a meshwork vascular pattern, in mice older than 6 months

liver hemorrhage ( J:241700 )

• scattered bleeding into necrotic and nonnecrotic liver areas with age

chronic liver inflammation ( J:241700 )

• liver shows a mononuclear chronic inflammatory infiltrate which is nonregionalized and patchy with areas of necrosis

• however, Mallory body formation is not seen, and no differences in white cell, platelet, or red blood cell counts or other serum chemistry are seen

abnormal hepatocyte morphology ( J:241700 )

• collagenase liver perfusion of young mice at an early stage when inflammation and necrosis are mild results in significant cell death indicating hepatocyte fragility

hepatic necrosis ( J:241700 )

• necrosis and bleeding into necrotic and nonnecrotic areas becomes highly prominent with age

homeostasis/metabolism

increased circulating alanine transaminase level ( J:241700 )

• elevation in serum glutamic-pyruvic transaminase

increased circulating aspartate transaminase level ( J:241700 )

• elevation in serum glutamic-oxaloacetic transaminase

cardiovascular system

abnormal liver vasculature morphology ( J:241700 )

• livers show increased prominence of the vascular subcapsular markings, with appearance of a punctate pattern rather than a meshwork vascular pattern, in mice older than 6 months

liver hemorrhage ( J:241700 )

• scattered bleeding into necrotic and nonnecrotic liver areas with age

immune system

chronic liver inflammation ( J:241700 )

• liver shows a mononuclear chronic inflammatory infiltrate which is nonregionalized and patchy with areas of necrosis

• however, Mallory body formation is not seen, and no differences in white cell, platelet, or red blood cell counts or other serum chemistry are seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatitis		DOID:2237		J:241700