Phenotypes associated with this allele

• Allele Symbol: Cep20^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:7263004
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cep20^tm1.1(KOMP)Vlcg/Cep20^tm1.1(KOMP)Vlcg	B6(Cg)-Cep20^tm1.1(KOMP)Vlcg	MGI:7263082

Genotype
MGI:7263082

hm1

• Allelic Composition: Cep20^{tm1.1(KOMP)Vlcg}/Cep20^{tm1.1(KOMP)Vlcg}
• Genetic Background: B6(Cg)-Cep20^{tm1.1(KOMP)Vlcg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:308526 )

• no live-born pups are obtained, fewer than the expected number of embryos are seen at E11.5, but not at E8.5 to E10.5, and no embryos are detected beyond E11.5 indicating lethality around E10.5-E11.5

growth/size/body

embryonic growth retardation ( J:308526 )

• embryos exhibit mild developmental delay at E9.5 and severe development delay at E10.5

decreased embryo size ( J:308526 )

• embryos are smaller at E9.5 and E10.5

embryo

abnormal vitelline vasculature morphology ( J:308526 )

• yolk sacs develop a meshwork-like primitive vessel network at E9.5 and lack perfusion at E10.5 instead of being well vascularized and well perfused like wild-type embryos

failure of initiation of embryo turning ( J:308526 )

• all embryos fail turning at the 8-13 somite stage and do not curl

abnormal left-right axis patterning ( J:308526 )

• defective left-right patterning as indicated by disorganized heart looping and failure of embryonic turning

caudal body truncation ( J:308526 )

• E10.5 embryos exhibit a truncated posterior trunk

embryonic growth arrest ( J:308526 )

• embryos arrest at the 10-14 somite stage

embryonic growth retardation ( J:308526 )

• embryos exhibit mild developmental delay at E9.5 and severe development delay at E10.5

decreased embryo size ( J:308526 )

• embryos are smaller at E9.5 and E10.5

abnormal primitive node morphology ( J:308526 )

• the embryonic nodes vary in size and shape in embryos, although no significant difference in size is seen

absent embryonic cilia ( J:308526 )

• no cilia or cilia-like structure is seen in the embryonic node

abnormal amniotic cavity morphology ( J:308526 )

• amniotic cavity is dramatically enlarged in E10.5 embryos

failure of chorioallantoic fusion ( J:308526 )

• E9.5 embryos exhibit failure in chorioallantoic fusion

cardiovascular system

abnormal angiogenesis ( J:308526 )

• embryos show defective angiogenesis in yolk sacs and embryos

abnormal developmental vascular remodeling ( J:308526 )

• embryos only have a primitive cephalic vasculature at E9.5, indicating a failure in the remodeling of the primitive vascular plexus

abnormal vitelline vasculature morphology ( J:308526 )

• yolk sacs develop a meshwork-like primitive vessel network at E9.5 and lack perfusion at E10.5 instead of being well vascularized and well perfused like wild-type embryos

abnormal heart development ( J:308526 )

• embryos exhibit an abnormally developed heart

abnormal direction of heart looping ( J:308526 )

• about 57% of embryos exhibit nontypical L- or D-LOOP looping (middle) or reversed cardiac looping (D-LOOP) type heart looping

pericardial edema ( J:308526 )

• E10.5 embryos exhibit pericardial edema

enlarged pericardium ( J:308526 )

• embryos exhibit an abnormally developed heart with an enlarged pericardium

homeostasis/metabolism

pericardial edema ( J:308526 )

• E10.5 embryos exhibit pericardial edema

cellular

absent embryonic cilia ( J:308526 )

• no cilia or cilia-like structure is seen in the embryonic node