Phenotypes associated with this allele

• Allele Symbol: Acox2^em1Jynz
• Allele Name: endonuclease-mediated mutation 1, Jian-Yuan Zhao
• Allele ID: MGI:7263204
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Acox2^em1Jynz/Acox2^em1Jynz	involves: C57BL/6N	MGI:7263210

Genotype
MGI:7263210

hm1

• Allelic Composition: Acox2^em1Jynz/Acox2^em1Jynz
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased liver tumor incidence ( J:323193 )

• 28.57% of mice spontaneously develop liver cancer at 8-9 months of age

liver/biliary system

bile duct proliferation ( J:323193 )

• mice exhibit bile duct proliferation

liver inflammation ( J:323193 )

• mice exhibit inflammatory infiltration in liver tissues, with predominately CD20+ B-lymphocytes, followed by CD3+ T-lymphocytes and CD138+ plasma cells, with almost no CD68+ macrophages

increased liver tumor incidence ( J:323193 )

• 28.57% of mice spontaneously develop liver cancer at 8-9 months of age

immune system

liver inflammation ( J:323193 )

• mice exhibit inflammatory infiltration in liver tissues, with predominately CD20+ B-lymphocytes, followed by CD3+ T-lymphocytes and CD138+ plasma cells, with almost no CD68+ macrophages

endocrine/exocrine glands

bile duct proliferation ( J:323193 )

• mice exhibit bile duct proliferation