Phenotypes associated with this allele

• Allele Symbol: 4933425B07Rik^{Tn(pb-Act-RFP)1.1Zhu}
• Allele Name: transposon insertion 1.1, Yuan Zhuang
• Allele ID: MGI:7266255
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	4933425B07Rik^Tn(pb-Act-RFP)1.1Zhu/4933425B07Rik^Tn(pb-Act-RFP)1.1Zhu	involves: FVB/NJ	MGI:7424963
cx2	4933425B07Rik^Tn(pb-Act-RFP)1.1Zhu/4933425B07Rik^Tn(pb-Act-RFP)1.1Zhu Tg(Hoxb7-Venus*)17Cos/0	involves: C57BL/6J * CBA/J * FVB/NJ	MGI:7424971

Genotype
MGI:7424963

hm1

• Allelic Composition: 4933425B07Rik^{Tn(pb-Act-RFP)1.1Zhu}/4933425B07Rik^{Tn(pb-Act-RFP)1.1Zhu}
• Genetic Background: involves: FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal renal/urinary system morphology ( J:313930 )

• newborn mice exhibit a significantly higher incidence (66.7%) of congenital anomalies of the kidney and urinary tract (CAKUT) than heterozygous (10.4%) or wild-type mice (9.3%)

abnormal kidney morphology ( J:313930 )

• 82.4% of newborns exhibit renal hypo/dysplasia

decreased renal glomerulus number ( J:313930 )

• newborns with hydronephrosis show a reduced number of glomeruli

• however, newborns with renal hypo/dysplasia and duplex kidneys show normal glomerulus structure and morphology

hydronephrosis ( J:313930 )

• 5.9% of newborns exhibit hydronephrosis, along with decreased numbers of glomeruli and renal tubules

renal hypoplasia ( J:313930 )

• 82.4% of newborns exhibit renal hypo/dysplasia

decreased renal tubule number ( J:313930 )

• newborns with hydronephrosis show a reduced number of renal tubules

• however, newborns with renal hypo/dysplasia and duplex kidneys show normal renal tubule structure and morphology

duplex kidney ( J:313930 )

• 8.8% of newborns exhibit duplex renal/collecting system

vesicoureteral reflux ( J:313930 )

• 2.9% of newborns exhibit vesicoureteral reflux

Genotype
MGI:7424971

cx2

• Allelic Composition: 4933425B07Rik^{Tn(pb-Act-RFP)1.1Zhu}/4933425B07Rik^{Tn(pb-Act-RFP)1.1Zhu}; Tg(Hoxb7-Venus*)17Cos/0
• Genetic Background: involves: C57BL/6J * CBA/J * FVB/NJ

renal/urinary system

abnormal metanephric ureteric bud development ( J:313930 )

• expression levels of Bmp4 (a key gene regulating ureteral bud branching) are significantly reduced in the embryonic kidney during the early UB branching stages

impaired branching involved in ureteric bud morphogenesis ( J:313930 )

• in vitro, E11.5 embryonic kidneys show a significantly lower number of ureteric bud (UB) branches than control kidneys after 24, 48, and 72 h in culture