mortality/aging
• mice die before they are old enough to be tested on the rotarod
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growth/size/body
• weight gain between P14 and P22 is attenuated
• males weigh less than Eef1a2em1Abb homozygous males at 15 days of age, and fail to gain weight thereafter
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behavior/neurological
• mice show worse neuroscores (consisting of the severity of impairment on ledge walking, hindlimb clasping, gait and kyphosis) than wild-type mice or null Eef1a2em1Abb mice and this neurological dysfunction worsens progressively from 16-23 days
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nervous system
• spinal cord shows abnormal pathology, including loss of normal nuclear structure with apparent loss of nuclear membrane leading to neuronal death in anterior horn motor neurons
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• spinal cord shows neuronal death in anterior horn motor neurons
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