mortality/aging
• mice show a high number of sudden deaths and spontaneous fatal seizures around 22 days of age
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growth/size/body
• weight gain between P14 and P22 is attenuated
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behavior/neurological
• mice show spontaneous fatal seizures around 22 days of age
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nervous system
• mice show spontaneous fatal seizures around 22 days of age
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• spinal cord shows abnormal pathology, including loss of normal nuclear structure with apparent loss of nuclear membrane leading to neuronal death in anterior horn motor neurons
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• spinal cord shows neuronal death in anterior horn motor neurons
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