About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rnaseh2bem1Anu
endonuclease-mediated mutation 1, Australian National University
MGI:7279261
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rnaseh2bem1Anu/Rnaseh2bem1Anu C57BL/6NCrl-Rnaseh2bem1Anu MGI:7284991
cx2
 		Rnaseh2bem1Anu/Rnaseh2b+
Tlr7em2Anu/Tlr7+ 		C57BL/6NCrl-Rnaseh2bem1Anu Tlr7em2Anu MGI:7284994


Genotype
MGI:7284991
hm1
Allelic
Composition		 Rnaseh2bem1Anu/Rnaseh2bem1Anu
Genetic
Background		 C57BL/6NCrl-Rnaseh2bem1Anu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseh2bem1Anu mutation (0 available); any Rnaseh2b mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7284994
cx2
Allelic
Composition		 Rnaseh2bem1Anu/Rnaseh2b+
Tlr7em2Anu/Tlr7+
Genetic
Background		 C57BL/6NCrl-Rnaseh2bem1Anu Tlr7em2Anu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseh2bem1Anu mutation (0 available); any Rnaseh2b mutation (43 available)
Tlr7em2Anu mutation (0 available); any Tlr7 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system morphology ( J:324448 )
• mice show a similar phenotype seen in female heterozygous Tlr7em2Anu mice with no exacerbation of the cellular or serological phenotypes seen in these mice except for a mild enhancement in the expression of type I IFN signature genes
increased plasma cell number ( J:324448 )
• spleen shows an increase in plasma cells
increased CD4-positive, alpha-beta T cell number ( J:324448 )
• CXCR3+ extrafollicular helper CD4+ T cells are increased
abnormal mature B cell morphology ( J:324448 )
• spleen shows an increase in age-associated B cells (B220+CD21-CXCR5-CD19hiCD11c+)
• age-associated B cells are also expanded in the blood and kidneys
increased germinal center B cell number ( J:324448 )
• increase in germinal center B cells (CD19+CD95+BCL6+)
increased autoantibody level ( J:324448 )
• mice develop autoantibodies to the TLR7 ligands ssRNA and Smith protein ribonucleoprotein (RNP) and DNA

hematopoietic system
increased plasma cell number ( J:324448 )
• spleen shows an increase in plasma cells
increased CD4-positive, alpha-beta T cell number ( J:324448 )
• CXCR3+ extrafollicular helper CD4+ T cells are increased
abnormal mature B cell morphology ( J:324448 )
• spleen shows an increase in age-associated B cells (B220+CD21-CXCR5-CD19hiCD11c+)
• age-associated B cells are also expanded in the blood and kidneys
increased germinal center B cell number ( J:324448 )
• increase in germinal center B cells (CD19+CD95+BCL6+)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory