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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rnaseh2bem1Anu
endonuclease-mediated mutation 1, Australian National University
MGI:7279261
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rnaseh2bem1Anu/Rnaseh2bem1Anu C57BL/6NCrl-Rnaseh2bem1Anu MGI:7284991
cx2
 		Rnaseh2bem1Anu/Rnaseh2b+
Tlr7em2Anu/Tlr7+ 		C57BL/6NCrl-Rnaseh2bem1Anu Tlr7em2Anu MGI:7284994


Genotype
MGI:7284991
hm1
Allelic
Composition		 Rnaseh2bem1Anu/Rnaseh2bem1Anu
Genetic
Background		 C57BL/6NCrl-Rnaseh2bem1Anu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseh2bem1Anu mutation (0 available); any Rnaseh2b mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7284994
cx2
Allelic
Composition		 Rnaseh2bem1Anu/Rnaseh2b+
Tlr7em2Anu/Tlr7+
Genetic
Background		 C57BL/6NCrl-Rnaseh2bem1Anu Tlr7em2Anu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnaseh2bem1Anu mutation (0 available); any Rnaseh2b mutation (43 available)
Tlr7em2Anu mutation (0 available); any Tlr7 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system morphology ( J:324448 )
• mice show a similar phenotype seen in female heterozygous Tlr7em2Anu mice with no exacerbation of the cellular or serological phenotypes seen in these mice except for a mild enhancement in the expression of type I IFN signature genes
increased plasma cell number ( J:324448 )
• spleen shows an increase in plasma cells
increased CD4-positive, alpha-beta T cell number ( J:324448 )
• CXCR3+ extrafollicular helper CD4+ T cells are increased
abnormal mature B cell morphology ( J:324448 )
• spleen shows an increase in age-associated B cells (B220+CD21-CXCR5-CD19hiCD11c+)
• age-associated B cells are also expanded in the blood and kidneys
increased germinal center B cell number ( J:324448 )
• increase in germinal center B cells (CD19+CD95+BCL6+)
increased autoantibody level ( J:324448 )
• mice develop autoantibodies to the TLR7 ligands ssRNA and Smith protein ribonucleoprotein (RNP) and DNA

hematopoietic system
increased plasma cell number ( J:324448 )
• spleen shows an increase in plasma cells
increased CD4-positive, alpha-beta T cell number ( J:324448 )
• CXCR3+ extrafollicular helper CD4+ T cells are increased
abnormal mature B cell morphology ( J:324448 )
• spleen shows an increase in age-associated B cells (B220+CD21-CXCR5-CD19hiCD11c+)
• age-associated B cells are also expanded in the blood and kidneys
increased germinal center B cell number ( J:324448 )
• increase in germinal center B cells (CD19+CD95+BCL6+)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory